| Title | Year | Support | Creator | Editor | Country |
|---|---|---|---|---|---|
| ScanSwap | 2008 | Browser (Flash) | Succubus Interactive | @DOC Solutions | France |
| Scare Me Away | 2009 | Browser (Flash) | Brian Crick | Jennifer Ann's Group | U.S.A. |
| Scholastic's The Magic School Bus Explores in the Age of Dinosaurs | 1996 | PC (Windows) | Music Pen | Microsoft Corporation | U.S.A. |
| Scholastic's The Magic School Bus Explores Inside the Earth | 1996 | PC (Windows) | Music Pen | Scholastic | U.S.A. |
| Scholastic's The Magic School Bus Explores the Human Body | 1994 | Macintosh / PC (Windows) | Music Pen | Microsoft Corporation | U.S.A. |
| Scholastic's The Magic School Bus Explores the Ocean | 1995 | Macintosh / PC (Windows) | Music Pen | Microsoft Corporation | U.S.A. |
| Scholastic's The Magic School Bus Explores the Rainforest | 1997 | PC (Windows) | Music Pen | Microsoft Corporation | U.S.A. |
| Scholastic's The Magic School Bus: Space Exploration Game | 1995 | Genesis (Megadrive) | Novotrade International | SEGA of America | Hungary |
| School House: 30 Educational Programs | 1991 | PC (Dos) | MST Inc. | ||
| Schoolhouse | 1991 | PC (Dos) | Intentional Educations | Maverick Software | |
| Science and Technology Game | 2006 | PC (Windows) | Memet ÜÇGÜL | Memet ÜÇGÜL | Turkey |
| Science en jeu | 2008 | Browser (Flash) | CREO | CREO | Canada |
| Science Pirates: The Curse of Brownbeard | 2009 | Macintosh / PC (Windows) | New Mexico State University (USA) Learning Games Lab | New Mexico State University (USA) – US Department of Agriculture | U.S.A. |
| Science Supremo | 2008 | Browser (Flash) | DESQ | Sheffield Hallam University Centre for Science Education / Wellcome Trust / NESTA. | United Kingdom |
| Scooby-Doo: Case File #1: The Glowing Bug Man | 2002 | PC (Windows) | Riverdeep Interactive Learning Limited | Riverdeep Interactive Learning Limited | U.S.A. |
| Scooter's Magic Castle | 1993 | PC (Dos) | Electronic Arts | EA*Kids | U.S.A. |
| Scrabble | 1992 | Amiga / Atari ST / PC (Dos) | U.S. Gold Ltd. | U.S. Gold Ltd. | |
| Scrambled | 2007 | Macintosh / PC (Windows) | Red Rover Games | Red Rover Games | U.S.A. |
| Scratch My Car | 2007 | Browser (Flash) | Ubi Soft | Ubi Soft | France |
| Scribble Maze | 1999 | Browser | Hersey | Hersey | U.S.A. |
| Scribblr | 2011 | iPhone / iPod Touch / iPad | OmNom Apps | OmNom Apps | |
| Scuola del Brivido, La: Il piccolo Freakstein | 1998 | Macintosh / PC (Windows) | Lightbox Creative Software | EDI GROUP s.r.l. | Italy |
| Scuttle Buggery | 2009 | Browser (Flash) | My Pet Skeleton Productions | Johnny Hollow | |
| Seasons | 2004 | PC (Windows) | Sugar Games | Sugar Games | Russia |
| SeaWorld Adventure Parks Tycoon | 2003 | PC (Windows) | Deep Red Games Ltd. | Activision Value Publishing | United Kingdom |
| Second Life | 2003 | Macintosh / PC (Windows) | Linden Lab | Linden Lab | U.S.A. |
| Secret Agent Barbie | 2001 | PC (Windows) | Gigawatt Studios | Vivendi Universal Games | U.S.A. |
| SecretCam | 2011 | Macintosh / PC (Linux) / PC (Windows) | CNAM PAYS DE LA LOIRE | CNAM PAYS DE LA LOIRE | France |
| Secrets of Great Art | 2007 | PC (Windows) | Dekovir Entertainment | Reflexive Entertainment Inc. | Russia |
| Secrets of the Pyramids | 1994 | PC (Windows) | Ednovation | Mindscape | U.S.A. |
| See the U.S.A. | 1987 | PC (Dos) | Compu-Teach | Compu-Teach | |
| Sega Swirl | 1999 | Dreamcast / Palm (OS) / PC (Windows) | SEGA Corporation | ||
| Seismic Duck | 2010 | PC (Windows) | Arch D. Robison | Arch D. Robison | U.S.A. |
| Sellardore Tales | 2002 | Macintosh / PC (Windows) | Topologika Software Ltd. | Topologika Software Ltd. | United Kingdom |
| Sematic | 2012 | Solar Games | Centre de ressources Autistes du CHU de Nice-Lenval et le laboratoire LAPCOS de l’UNS | France | |
| Sensory Handicap | 2008 | Browser (Flash) | Ubisoft | Handicap International | France |
| September 12th: a toy world | 2003 | Browser | Gonzalo Frasca | News gaming | Uruguay |
| Serious Game du Flocon à la Vague | 2010 | Browser / PC (Windows) | France | ||
| SERIOUS GAMES Véhicule Electrique et Hybrique | 2010 | PC (Windows) | GNFA (Groupement National Formation Automobile - PMSI) | GNFA (Groupement National Formation Automobile - PMSI) | France |
| Sesame Street 1 2 3 | 1989 | NES (Famicom) | Zippo Games | Hi-Tech Expressions | U.S.A. |
| Sesame Street A B C | 1989 | NES (Famicom) | Zippo Games | Hi-Tech Expressions | |
| Sesame Street Countdown | 1992 | NES (Famicom) | Riedel Software Productions | Hi-Tech Expressions | U.S.A. |
| Sesame Street Crayon: Letters For You | 1987 | Apple II / Commodore 64 | Brian A. Rice | Polarware | U.S.A. |
| Sesame Street Crayon: Numbers Count | 1987 | Amiga / Apple II / Commodore 64 | Brian A. Rice | Polarware | U.S.A. |
| Sesame Street: Counting Cafe | 1994 | Genesis (Megadrive) | Electronic Arts | Electronic Arts | U.S.A. |
| Sesame Street: Get Set To Learn | 1996 | PC (Windows) | Creative Wonders LLC | Electronic Arts | U.S.A. |
| Sesame Street: Lets Make a Word! | 1995 | PC (Windows) | Creative Wonders LLC | EA*Kids | U.S.A. |
| Sesame Street: Letter-Go-Round | 1984 | Atari 800 / Commodore 64 / PC (Dos) | CTW Software Group | CBS Software | U.S.A. |