| Title | Year | Support | Creator | Editor | Country |
|---|---|---|---|---|---|
| RePlay: Finding Zoe | 2007 | Browser (Flash) | Take Action Games | METRAC | U.S.A. |
| Rocky's Boots | 1982 | Apple II / PC (Dos) | The Learning Co. | The Learning Co. | U.S.A. |
| Straight Shooter! | 2003 | PC (Windows) | games2train | Bankers Trust | U.S.A. |
| The Monkey Wrench Conspiracy | 2003 | PC (Windows) | games2train | Think3 | U.S.A. |
| Roulette, States | 1972 | Odyssey | Magnavox | Magnavox | U.S.A. |
| The Rugrats Movie: Activity Challenge | 1998 | Macintosh / PC (Windows) | Brøderbund Software | Brøderbund Software | U.S.A. |
| Rumpelstiltskin's Labyrinth of the Lost | 1995 | PC (Windows) | TerraGlyph Interactive Studios | TerraGlyph Interactive Studios | U.S.A. |
| Scholastic's The Magic School Bus Explores the Ocean | 1995 | Macintosh / PC (Windows) | Music Pen | Microsoft Corporation | U.S.A. |
| Scooby-Doo: Case File #1: The Glowing Bug Man | 2002 | PC (Windows) | Riverdeep Interactive Learning Limited | Riverdeep Interactive Learning Limited | U.S.A. |
| The Secret Island of Dr. Quandary | 1992 | PC (Dos) / Macintosh | MECC | MECC | U.S.A. |
| Secrets of the Pyramids | 1994 | PC (Windows) | Ednovation | Mindscape | U.S.A. |
| Sesame Street: Counting Cafe | 1994 | Genesis (Megadrive) | Electronic Arts | Electronic Arts | U.S.A. |
| Sesame Street Crayon: Numbers Count | 1987 | Amiga / Apple II / Commodore 64 | Brian A. Rice | Polarware | U.S.A. |
| Sesame Street: Lets Make a Word! | 1995 | PC (Windows) | Creative Wonders LLC | EA*Kids | U.S.A. |
| Sesame Street: Letter-Go-Round | 1984 | Atari 800 / Commodore 64 / PC (Dos) | CTW Software Group | CBS Software | U.S.A. |
| Sid the Spellbinder | 1982 | Magnavox Odyssey² (Videopac) | North American Philips Consumer Electronics Corp. | North American Philips Consumer Electronics Corp. | U.S.A. |
| Slater & Charlie Go Camping | 1993 | PC (Dos) / Macintosh | Sierra On-Line | Sierra On-Line | U.S.A. |
| Smurf: Paint 'n' Play Workshop | 1984 | ColecoVision | Coleco | Coleco | U.S.A. |
| Smurfs Save the Day | 1983 | Atari 2600 | Coleco | Coleco | U.S.A. |
| Snap Dragon | 1992 | PC (Dos) | MECC | MECC | U.S.A. |
| Snooper Troops | 1982 | Apple II / Atari 800 / Commodore 64 / PC (Dos) | Tom Snyder Productions | Spinnaker Software Corporation | U.S.A. |
| Snooper Troops: Case #2 - The Case of the Disappearing Dolphin | 1982 | Apple II / Atari 800 / Commodore 64 / PC (Dos) | Tom Snyder Productions | Spinnaker Software Corporation | U.S.A. |
| Spell Castle | 1986 | PC (Dos) | ComputerEasy | ComputerEasy | U.S.A. |
| Spelunx and the Caves of Mr. Seudo | 1991 | Macintosh / PC (Windows) | Cyan | Brøderbund Software | U.S.A. |
| SpongeBob SquarePants: Typing | 2004 | Macintosh / PC (Windows) | ImaginEngine Corp. | Riverdeep Interactive Learning Limited | U.S.A. |
| Spy Fox 2: Some Assembly Required | 1999 | Macintosh / PC (Windows) | Humongous Entertainment | Humongous Entertainment | U.S.A. |
| Spy Fox in "Dry Cereal" | 1997 | Macintosh / Wii / PC (Windows) | Humongous Entertainment | Humongous Entertainment | U.S.A. |
| Spy Kids Learning Adventures: Mission: The Candy Conspiracy | 2004 | PC (Windows) | Finite Monkeys | Brighter Minds Media | U.S.A. |
| Spy Kids Learning Adventures: Mission: The Underground Affair | 2004 | Macintosh / PC (Windows) | Finite Monkeys | Brighter Minds Media | U.S.A. |
| Star Wars: Anakin's Speedway | 1999 | PC (Windows) | Lucas Learning Ltd. | Lucas Learning Ltd. | U.S.A. |
| The Simpsons Movie: Wrecking Ball | 2007 | Browser (Flash) | Fox Interactive Studios | Twentieth Century Fox | U.S.A. |
| Stickybear: Preschool | 1994 | CD-i | Optimum Resource | Philips Interactive Media | U.S.A. |
| Storybook Weaver Deluxe | 1994 | Macintosh / PC (Windows) | MECC | MECC | U.S.A. |
| WindFall | 2009 | Browser (Flash) | Persuasive Games LLC | Persuasive Games LLC | U.S.A. |
| Supercharged! | 2003 | PC (Windows) | The Education Arcade | The Education Arcade | U.S.A. |
| Fletcher Library Game Project | 2006 | Browser (Flash) | Tammy Allgood | West Campus at Arizona State University | U.S.A. |
| Team Xtreme: Operation Weather Disaster | 1995 | Macintosh / PC (Windows) | Human Code | Discovery Channel Multimedia | U.S.A. |
| Thinkin' Things Collection 2 | 1995 | Macintosh / PC (Windows) | Edmark Corporation | Edmark Corporation | U.S.A. |
| Thomas and Friends: Thomas Saves the Day | 2003 | PC (Windows) | Stunt Puppy Entertainment | Atari Interactive | U.S.A. |
| The Time Warp of Dr. Brain | 1996 | Macintosh / PC (Windows) | Sierra On-Line | Sierra On-Line | U.S.A. |
| Treasure Cove! + Treasure Mountain! | 1999 | PC (Dos) / Macintosh / PC (Windows) | The Learning Company | The Learning Company | U.S.A. |
| Trivia Machine | 2004 | Macintosh / PC (Windows) | HipSoft LLC | Alawar Entertainment | U.S.A. |
| Vet Emergency 2 | 2003 | Macintosh / PC (Windows) | Legacy Interactive Inc. | Legacy Interactive Inc. | U.S.A. |
| Videocart-6: Math Quiz I - Addition, Subtraction | 1977 | Channel F | Fairchild Camera and Instrument Corp. | Luxor | U.S.A. |
| Videocart-7: Math Quiz II - Multiplication, Division | 1977 | Channel F | Fairchild Camera and Instrument Corp. | Fairchild Camera and Instrument Corp. | U.S.A. |
| Vintage Gaming Trivia Challenge | 2005 | PC (Windows) | KNURDZ Entertainment | OlderGames | U.S.A. |
| The War College: Universal Military Simulator 3 | 1995 | PC (Dos) | Intergalactic Development Incorporated | GameTek UK Ltd. | U.S.A. |
| Where in Europe is Carmen Sandiego? | 1988 | Amiga / Apple II / Commodore 64 / PC (Dos) | Brøderbund Software | Brøderbund Software | U.S.A. |